Unaccustomed Earth, though it jumps between stories and people, has, as a result, multiple settings during different narratives. The various people live or are present in, at various points in the story, in Boston, Seattle, New York, the greater New England Area, England, Italy, India (New Delhi or Calcutta), and Thailand. The story itself doesn't differentiate greatly in how the settings are treated amongst the different American cities or towns. They are used, in general, as a juxtaposition between the cultures of Indian and America which are held against each other between the different generations (those who came to America and those who were born here). India, on the other hand, is often a place the older relatives go back to or the families go back to for various periods of time. It is the original culture, and often represents an internal crisis for those children of Indian parents who were born in America.
There also remains England and Italy. England is interesting because it also represents a disconnection from the family, but is less cultural and rather a more general growing apart. Italy also represents a shift in tone, becoming less a familial story so much as a love story which has a dreamlike, unreal quality because the lovers in question are taking a break from their lives, in a state of limbo.